Effects on NF-κB1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome

@article{Rousset1996EffectsON,
  title={Effects on NF-κB1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome},
  author={Rapha{\"e}l Rousset and Christelle Desbois and Fr{\'e}d{\'e}ric Bantignies and Pierre Jalinot},
  journal={Nature},
  year={1996},
  volume={381},
  pages={328-331}
}
THE viral Tax protein, which is encoded by human T-cell leukaemia virus HTLV-I, activates nuclear translocation of the NF-κB/Rel transcription factors and relieves cytoplasmic sequestration of RelA and Rel by heterodimerization with NF-κB1/p105 (refs 1,2). Proteolytic maturation of this precursor protein is performed by the proteasome complex3,4. Here we… CONTINUE READING