Effects on Mycobacterium avium replication in normal human macrophages by deferiprone (L1) and other iron chelators. Possible implications on toxicity.

@article{Douvas2002EffectsOM,
  title={Effects on Mycobacterium avium replication in normal human macrophages by deferiprone (L1) and other iron chelators. Possible implications on toxicity.},
  author={George S. Douvas and Mary H. May and Annita Kolnagou and George J Kontoghiorghes},
  journal={Arzneimittel-Forschung},
  year={2002},
  volume={52 1},
  pages={
          45-52
        }
}
Mycobacterium avium growth in cultured human macrophages is influenced by serum lipids, transferrin and iron levels. Iron-saturated transferrin enhances M. avium growth, whereas apotransferrin inhibits mycobacterial replication. The ability of iron chelators to mimic the effects of transferrin on intracellular and extracellular M. avium growth was examined. Smooth, transparent, AIDS patient derived M. avium 7497 scrovar 4 was used to infect 7-day cultured human macrophages. Growth was measured… CONTINUE READING