Effects on Murine Behavior and Lifespan of Selectively Decreasing Expression of Mutant Huntingtin Allele by Supt4h Knockdown

@inproceedings{Cheng2015EffectsOM,
  title={Effects on Murine Behavior and Lifespan of Selectively Decreasing Expression of Mutant Huntingtin Allele by Supt4h Knockdown},
  author={Hui-Min Cheng and Yijuang Chern and I-Hui Chen and Chia-Rung Liu and Sih-Huei Li and Seung Jong Chun and Frank Rigo and Christopher F. Bennett and Ning Deng and Yanan Feng and Chyuan-Sheng Lin and Yu-Ting Yan and Stanley N. Cohen and Tzu-Hao Cheng},
  booktitle={PLoS genetics},
  year={2015}
}
Production of protein containing lengthy stretches of polyglutamine encoded by multiple repeats of the trinucleotide CAG is a hallmark of Huntington's disease (HD) and of a variety of other inherited degenerative neurological and neuromuscular disorders. Earlier work has shown that interference with production of the transcription elongation protein SUPT4H results in decreased cellular capacity to transcribe mutant huntingtin gene (Htt) alleles containing long CAG expansions, but has little… CONTINUE READING

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