Effects of zopiclone, flunitrazepam, triazolam and levomepromazine on the transient change in sleep-wake schedule: polygraphic study, and the evaluation of sleep and daytime condition.

@article{Kanno1993EffectsOZ,
  title={Effects of zopiclone, flunitrazepam, triazolam and levomepromazine on the transient change in sleep-wake schedule: polygraphic study, and the evaluation of sleep and daytime condition.},
  author={Osamu Kanno and H. Watanabe and Hajime Kazamatsuri},
  journal={Progress in neuro-psychopharmacology \& biological psychiatry},
  year={1993},
  volume={17 2},
  pages={
          229-39
        }
}

Influence of zopiclone, a new generation hypnotic, on the intermediate stage and paradoxical sleep in the rat

The influence of zopiclone, a third generation hypnotic, on the transition from slow wave sleep to paradoxical sleep (PS) which is increased at the expense of PS by barbiturates and benzodiazepines is examined.

Zolpidem and triazolam do not affect the nocturnal sleep-induced memory improvement

The hypnotics tested did not interfere with the nocturnal sleep-induced improvement of memory and neither zolpidem nor triazolam affected the enhanced nonword recall observed after sleep.

Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers

Zopiclone and temazepam can be considered as effective hypnotics in elderly subjects when administered in that dosage and the superiority of zopiclones on sleep architecture may be related to a more specific action of zopylone at the GABA-A benzodiazepine receptor complex.

Zopiclone. An update of its pharmacology, clinical efficacy and tolerability in the treatment of insomnia.

Although the available data on rebound insomnia and dependence liability are encouraging, potential differences between zopiclone and the benzodiazepines in these respects may have little clinical relevance in the context of short term intermittent use of hypnotics, as it currently recommended.

A randomized, double-blind, single-dose, placebo-controlled, multicenter, polysomnographic study of gabapentin in transient insomnia induced by sleep phase advance.

  • R. RosenbergSteven G. Hull T. Roth
  • Medicine, Psychology
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
  • 2014
STUDY OBJECTIVES To evaluate the effects of single doses of gabapentin 250 and 500 mg on polysomnographic (PSG) and participant-reported sleep measures in a 5-h phase advance insomnia model.

A randomized, double-blind, placebo-controlled, multicenter, 28-day, polysomnographic study of gabapentin in transient insomnia induced by sleep phase advance.

Gabapentin 250 mg resulted in greater PSG and participant-reported sleep duration following a 5-h phase advance on Day 1 and Day 28 of use without evidence of next-day impairment, and greater sleep duration during at-home use.

Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists.

In both rats and normal sleeping individuals, agonistic modulators are able to reduce sleep latency, increase sleep continuity, and promote non-rapid-eye-movement (NREM) sleep as well as the occurrence of spindles, which implies that an activation of GABAA receptors plays a crucial role in the initiation and maintenance of NREM sleep and in the generation of sleep spindle activity.

Propofol versus flunitrazepam for inducing and maintaining sleep in postoperative ICU patients

Continuous low-dose injection of propofol for promoting and maintaining night sleep in ICU patients who are not analgo-sedated was superior to flunitrazepam regarding sleep quality and sleep structure.

Acute effects of melatonin on spontaneous and picrotoxin‐evoked sleep–wake behaviour in the rat

It is indicated that melatonin hardly influences sleep–wake behaviour in rats, and melatonin failed to attenuate the picrotoxin‐induced promotion of wakefulness.

Polysomnographic effects of hypnotic drugs

The problem of insomnia and the current ideas on polysomnography and hypnotic drugs are reconsiders in the light of newly acquired neurophysiological data on the microstructure of sleep.