Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling.

  title={Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling.},
  author={Sabina Frascarelli and Vittoria Carnicelli and Sandra Ghelardoni and Grazia Chiellini and Francesca Ronca and Riccardo Zucchi},
  journal={Journal of cardiovascular pharmacology},
  volume={54 5},
Isolated rat hearts were perfused for 120 minutes in the presence or in the absence of 10 microM zofenoprilat, the active metabolite of zofenopril. At the end of perfusion, cardiac tissue was used to assay sarcoplasmic reticulum (SR) (45)Ca uptake and SR calcium release, which was determined by automatized quick filtration technique after SR vesicle loading with (45)Ca. The expression of genes involved in the control of calcium homeostasis was evaluated by polymerase chain reaction after… CONTINUE READING
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