Effects of zimelidine on serotoninergic and noradrenergic neurons after repeated administration in the rat

Abstract

The effects of prolonged treatment of rats with zimelidine, 5, 12.5, and 25 μmol/kg PO twice daily for 2 weeks, on the accumulation of 14C-5-hydroxytryptamine (14C-5-HT) and 3H-noradrenaline (3H-NA) in hypothalamic slices were studied. The concentrations of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) in whole brain, the concentration of 5-HT in whole blood… (More)
DOI: 10.1007/BF00431820

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