Corpus ID: 23778517

Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting.

  title={Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting.},
  author={C. Maisonneuve and A. Igoudjil and K. Begriche and P. Lett{\'e}ron and Marie-Christine Guimont and J. Bastin and Jean-Pierre Laigneau and D. Pessayre and B. Fromenty},
  journal={Antiviral therapy},
  volume={9 5},
  • C. Maisonneuve, A. Igoudjil, +6 authors B. Fromenty
  • Published 2004
  • Biology, Medicine
  • Antiviral therapy
  • OBJECTIVE Although mitochondrial DNA (mtDNA) depletion could play a role in nucleoside reverse transcriptase inhibitor-induced lipoatrophy, poor correlations between fat mtDNA levels and lipoatrophy suggest additional mechanism(s). Stavudine (d4T), zidovudine (AZT) and the thymine catabolite, beta-aminoisobutyric acid (BAIBA), but not zalcitabine (ddC) or didanosine (ddI), can increase fatty acid oxidation in liver mitochondria and plasma ketone bodies in mice. Since fat oxidation in non… CONTINUE READING
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