Effects of yohimbine on autonomic measures are determined by individual values for area under the concentration-time curve.

Abstract

A study was conducted to examine tolerability and pharmacodynamics of single doses of yohimbine in healthy volunteers using measures of mood, heart rate, blood pressure, and serum catecholamine levels. Participants were given single oral doses of yohimbine hydrochloride as high as 21.6 mg. Plasma concentrations of yohimbine, epinephrine, norepinephrine, and… (More)

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@article{Grasing1996EffectsOY, title={Effects of yohimbine on autonomic measures are determined by individual values for area under the concentration-time curve.}, author={Kenneth Grasing and Marc G. Sturgill and Raymond C. Rosen and J Richard Trout and Thresia Thomas and Gururaj D Kulkarni and P Maines and James R. Seibold}, journal={Journal of clinical pharmacology}, year={1996}, volume={36 9}, pages={814-22} }