Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats

@article{Goloubkova2000EffectsOX,
  title={Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats},
  author={Tatiana Goloubkova and Maria Fl{\'a}via Marques Ribeiro and Luciene P. Rodrigues and Ana L{\'u}cia Cecconello and Poli Mara Spritzer},
  journal={Archives of Toxicology},
  year={2000},
  volume={74},
  pages={92-98}
}
Abstract Considerable attention has currently been focused on bisphenol A (BPA), an environmental endocrine disrupting chemical that has oestrogenic activity. In vitro and in vivo short-term assays have shown that BPA is weakly estrogenic. In addition, the issue of species- and strain-differences in susceptibility to BPA was raised. The treatment of ovariectomized (OVX) Wistar rats with BPA at doses of 11–250 mg/kg per day, s.c., for 7 days, resulted in significant dose-dependent re-growth of… 

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References

SHOWING 1-10 OF 52 REFERENCES

The xenoestrogen bisphenol A induces growth, differentiation, and c-fos gene expression in the female reproductive tract.

TLDR
The studies demonstrate that the molecular and morphological alterations induced by BPA in the uterus and vagina are nearly identical to those induced by estradiol; the vagina appears to be especially sensitive to the estrogenic actions of BPA.

Effects of bromocriptine on serum prolactin levels, pituitary weight and immunoreactive prolactin cells in estradiol-treated ovariectomized rats: an experimental model of estrogen-dependent hyperprolactinemia.

  • M. RibeiroP. Spritzer F. Reis
  • Biology, Medicine
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 1997
TLDR
The general antiprolact inemic and antiproliferative pituitary effects of bromocriptine treatment reported here validate the experimental model of estrogen-induced hyperprolactinemic rats.

Effects of tamoxifen on serum prolactin levels, pituitary immunoreactive prolactin cells and uterine growth in estradiol-treated ovariectomized rats.

TLDR
The results of the present paper showed that tamoxifen reduced estrogen-stimulated prolactin levels in some, but not in other hormonal conditions and that these effects were not mediated by an inhibition of lactotroph cell growth.

Profound effects of the weak environmental estrogen-like chemical bisphenol A on the growth of the mammary gland of Noble rats

The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo.

TLDR
BPA mimics estradiol in inducing hyperprolactinemia in genetically predisposed rats and the in vivo action is mediated, at least in part, by increasing PRL regulating factor activity in the posterior pituitary.

Uterotrophic activity of bisphenol A in the immature rat.

TLDR
These results are consistent with those of Dodds and Lawson who found that BPA induces persistent vaginal cornification in ovariectomized rats exposed to three twice-daily injections of 85 mg/kg BPA, but they conflict with the reported inactivity of BPA in the immature mouse uterotrophic assay.

Several environmental oestrogens are also anti-androgens.

TLDR
It is shown that many of the so-called 'environmental oestrogens' also possess anti-androgenic activity, demonstrating that hormone-mimicking chemicals can have multiple hormonal activities, which may make it difficult to interpret their mechanisms of action in vivo.

Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay.

TLDR
Even short-term exposure to most of the xenobiotic estrogens can induce typical estrogenic effects in vivo, but their estrogenic potency is very weak even when assessed in an acute response.

Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol

Suppression of male-specific cytochrome P450 isoforms by bisphenol A in rat liver

TLDR
It is suggested that BPA affects male-specific P450 isoforms in rat liver, and that these changes closely relate to the toxicity of BPA.
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