Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats

  title={Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats},
  author={Tatiana Goloubkova and Maria Fl{\'a}via Marques Ribeiro and Luciene P. Rodrigues and Ana L{\'u}cia Cecconello and Poli Mara Spritzer},
  journal={Archives of Toxicology},
Abstract Considerable attention has currently been focused on bisphenol A (BPA), an environmental endocrine disrupting chemical that has oestrogenic activity. In vitro and in vivo short-term assays have shown that BPA is weakly estrogenic. In addition, the issue of species- and strain-differences in susceptibility to BPA was raised. The treatment of ovariectomized (OVX) Wistar rats with BPA at doses of 11–250 mg/kg per day, s.c., for 7 days, resulted in significant dose-dependent re-growth of… 

Effect of bisphenol a on occurrence and progression of prolactinoma and its underlying mechanisms.

BPA can significantly promote pituitary cell proliferation and prolactin secretion in F344 rats, which may have impact on the proliferation and secretion of pituitsary cell function through the ERα pathway.

Neonatal Exposure to Bisphenol A Alters Reproductive Parameters and Gonadotropin Releasing Hormone Signaling in Female Rats

It is demonstrated for the first time that neonatal in vivo BPA permanently affects GnRH pulsatility and pituitary GnRH signaling.

Effects of in utero and lactational exposure to bisphenol A on somatic growth and anogenital distance in F1 rat offspring.

It is suggested that prenatal and postnatal exposure (indirect exposure) to BPA does not affect on somatic growth or AGD of F1 generation of male and female rats, and there were no significant changes in body weight, liver weight, kidneys weight, testes weight, AGD.

Prenatal Exposure to Low Doses of Bisphenol A Increases Pituitary Proliferation and Gonadotroph Number in Female Mice Offspring at Birth1

Results show that prenatal exposure to BPA affects pituitary gonadotroph development in females, and male pituitaries showed no change in the parameters tested.

Potential estrogenic effects of bisphenol-A estimated by in vitro and in vivo combination assays.

It is demonstrated that BPA exhibits weak estrogenic activity in all experimental systems, and thus its migration from epoxy resins or polycarbonate products should be controlled not to exceed a safety levels for humans.

Evaluation of the immune response following exposure of mice to bisphenol A: Induction of th1 cytokine and prolactin by BPA exposure in the mouse spleen cells

It is suggested that stimulation of prolactin production by estrogenic effects of BPA would affect cytokine profiles, and lead to imbalanced cellular immune response, and it could speculate that Prolactin and cytokine is important mediator involved in network between neuroendocrine and immune system by BPA.

Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats.

  • R. TylC. Myers J. Waechter
  • Biology
    Toxicological sciences : an official journal of the Society of Toxicology
  • 2002
BPA should not be considered a selective reproductive toxicant, based on the results of this study, and no evidence of nonmonotonic dose-response curves across generations for either sex is found.

In vivo effects of bisphenol A in laboratory rodent studies.

Lack of Modifying Effects of Bisphenol A and Roasted-Ground Soybean (Kinako) on N-ethyl-N-nitrosourea-Induced Uterine Carcinogenesis in Heterozygous p53 Deficient CBA Mice

The results in the present study indicate that 1% BpA and 20% SB in diet have no modifying effects on uterine carcinogenesis in p53 (+/-) CBA mice initiated with ENU.



The xenoestrogen bisphenol A induces growth, differentiation, and c-fos gene expression in the female reproductive tract.

The studies demonstrate that the molecular and morphological alterations induced by BPA in the uterus and vagina are nearly identical to those induced by estradiol; the vagina appears to be especially sensitive to the estrogenic actions of BPA.

Effects of bromocriptine on serum prolactin levels, pituitary weight and immunoreactive prolactin cells in estradiol-treated ovariectomized rats: an experimental model of estrogen-dependent hyperprolactinemia.

  • M. RibeiroP. Spritzer F. Reis
  • Biology, Medicine
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 1997
The general antiprolact inemic and antiproliferative pituitary effects of bromocriptine treatment reported here validate the experimental model of estrogen-induced hyperprolactinemic rats.

Effects of tamoxifen on serum prolactin levels, pituitary immunoreactive prolactin cells and uterine growth in estradiol-treated ovariectomized rats.

The results of the present paper showed that tamoxifen reduced estrogen-stimulated prolactin levels in some, but not in other hormonal conditions and that these effects were not mediated by an inhibition of lactotroph cell growth.

Profound effects of the weak environmental estrogen-like chemical bisphenol A on the growth of the mammary gland of Noble rats

The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo.

BPA mimics estradiol in inducing hyperprolactinemia in genetically predisposed rats and the in vivo action is mediated, at least in part, by increasing PRL regulating factor activity in the posterior pituitary.

Uterotrophic activity of bisphenol A in the immature rat.

These results are consistent with those of Dodds and Lawson who found that BPA induces persistent vaginal cornification in ovariectomized rats exposed to three twice-daily injections of 85 mg/kg BPA, but they conflict with the reported inactivity of BPA in the immature mouse uterotrophic assay.

Several environmental oestrogens are also anti-androgens.

It is shown that many of the so-called 'environmental oestrogens' also possess anti-androgenic activity, demonstrating that hormone-mimicking chemicals can have multiple hormonal activities, which may make it difficult to interpret their mechanisms of action in vivo.

Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay.

Even short-term exposure to most of the xenobiotic estrogens can induce typical estrogenic effects in vivo, but their estrogenic potency is very weak even when assessed in an acute response.

Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol

Suppression of male-specific cytochrome P450 isoforms by bisphenol A in rat liver

It is suggested that BPA affects male-specific P450 isoforms in rat liver, and that these changes closely relate to the toxicity of BPA.