Effects of weight loss in massive obesity on insulin and C-peptide dynamics: sequential changes in insulin production, clearance, and sensitivity.

@article{Jimnez1987EffectsOW,
  title={Effects of weight loss in massive obesity on insulin and C-peptide dynamics: sequential changes in insulin production, clearance, and sensitivity.},
  author={Juana Jim{\'e}nez and S Z{\'u}{\~n}iga-Guajardo and Bernard Zinman and Aubie Angel},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1987},
  volume={64 4},
  pages={661-8}
}
In massively obese patients hyperinsulinemia and insulin insensitivity usually improve with weight loss. To clarify the mechanism of these reversible abnormalities eight nondiabetic massively obese patients were studied before and at intervals (3 months and 1 yr) after weight loss following gastroplasty. Insulin dynamics were studied during the hyperglycemic clamp (change in glucose, 7 mmol L-1 for 2 h) by measuring the area under the insulin and C-peptide response curves, representing… CONTINUE READING

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