Effects of weak acids, UV and proton motive force inhibitors on pyrazinamide activity against Mycobacterium tuberculosis in vitro.

@article{Wade2006EffectsOW,
  title={Effects of weak acids, UV and proton motive force inhibitors on pyrazinamide activity against Mycobacterium tuberculosis in vitro.},
  author={M. Wade and Y. Zhang},
  journal={The Journal of antimicrobial chemotherapy},
  year={2006},
  volume={58 5},
  pages={
          936-41
        }
}
  • M. Wade, Y. Zhang
  • Published 2006
  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
BACKGROUND Pyrazinamide is a paradoxical frontline tuberculosis drug characterized by high sterilizing in vivo activity but poor in vitro activity. Pyrazinamide is thought to act by the entrapment of pyrazinoic acid in the bacterial cell, leading to acidification and membrane damage. Consequently, the effects of weak acids and molecules affecting membranes added to pyrazinamide were studied. OBJECTIVES To examine the effects of weak acids, UV, oxidative stress and additional energy inhibitors… Expand
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