Effects of voriconazole on tacrolimus metabolism in a kidney transplant recipient.

@article{Capone2010EffectsOV,
  title={Effects of voriconazole on tacrolimus metabolism in a kidney transplant recipient.},
  author={Domenico Capone and Giovanni Tarantino and Antonio Gentile and Massimo Sabbatini and Giuliano Polichetti and Marco Santangelo and Riccardo Nappi and Alessandra Ciotola and Viviana D'Alessandro and Andrea Renda and Vincenzo Basile and Stefano Federico},
  journal={Journal of clinical pharmacy and therapeutics},
  year={2010},
  volume={35 1},
  pages={121-4}
}
Infection occurs frequently in the organ transplant recipients during the post-transplant period because of immunosuppression. Therefore, prophylactic antimicrobial agents are often used. The azole antifungals, widely prescribed prophylactically, are known to have many drug-drug interactions. This report presents a case of drug-drug interaction between voriconazole and tacrolimus in a kidney transplant recipient. Voriconazole treatment led to a dramatic increase in tacrolimus concentration that… CONTINUE READING
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