Effects of voriconazole on Cryptococcus neoformans.

  title={Effects of voriconazole on Cryptococcus neoformans.},
  author={David van Duin and Wendy Cleare and {\'O}scar Zaragoza and Arturo Casadevall and Joshua D Nosanchuk},
  journal={Antimicrobial agents and chemotherapy},
  volume={48 6},
Voriconazole is a broad-spectrum triazole that offers extended activity against molds and yeasts that are not susceptible to earlier azole-type drugs. Recent studies indicate that melanization can severely reduce the susceptibility of certain antifungal drugs, but there is no information as to whether voriconazole is vulnerable to this effect. The activity of voriconazole on C. neoformans was assessed by MIC analysis and time-kill assays for melanized and nonmelanized cells. Cell morphology… CONTINUE READING

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