Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome.

@article{LlorensMartn2010EffectsOV,
  title={Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome.},
  author={M Llorens-Mart{\'i}n and N. Martinez Rueda and Gonzalo Sanchez Tejeda and Jes{\'u}s Fl{\'o}rez and Jos{\'e} Luis Trejo and Carmen Mart{\'i}nez-Cu{\'e}},
  journal={Neuroscience},
  year={2010},
  volume={171 4},
  pages={1228-40}
}
The Ts65Dn (TS) mouse is the most widely used model of Down syndrome (DS). This mouse shares many phenotypic characteristics with the human condition including cognitive and neuromorphological alterations. In this study the effects of physical exercise on hippocampal neurogenesis and behavior in TS mice were assessed. 10-12 month-old male TS and control (CO) mice were submitted to voluntary physical exercise for 7 weeks and the effects of this protocol on hippocampal morphology, neurogenesis… CONTINUE READING
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IGF-I is required for running induced changes in adult hippocampal neurogenesis but not dendritic spines

  • ER lasper, MV Llorens-Martín, B Leuner, E Gould, JL Trejo
  • Hippocampus
  • 2010

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