Effects of volatile anesthetics on store-operated Ca(2+) influx in airway smooth muscle.

@article{Pabelick2004EffectsOV,
  title={Effects of volatile anesthetics on store-operated Ca(2+) influx in airway smooth muscle.},
  author={Christina M. Pabelick and Binnaz Ay and Y. K. Subrahmanya Prakash and Gary C. Sieck},
  journal={Anesthesiology},
  year={2004},
  volume={101 2},
  pages={373-80}
}
BACKGROUND In airway smooth muscle (ASM), volatile anesthetics deplete sarcoplasmic reticulum (SR) Ca(2+) stores by increasing Ca(2+) "leak." Accordingly, SR replenishment becomes dependent on Ca(2+) influx. Depletion of SR Ca(2+) stores triggers Ca(2+) influx via specific plasma membrane channels, store-operated Ca(2+) channels (SOCC). We hypothesized that anesthetics inhibit SOCC triggered by increased SR Ca(2+) "leak," preventing SR replenishment and enhancing ASM relaxation. METHODS In… CONTINUE READING

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