Effects of volatile and intravenous anesthetics on the uptake of GABA, glutamate and dopamine by their transporters heterologously expressed in COS cells and in rat brain synaptosomes.

@article{Sugimura2001EffectsOV,
  title={Effects of volatile and intravenous anesthetics on the uptake of GABA, glutamate and dopamine by their transporters heterologously expressed in COS cells and in rat brain synaptosomes.},
  author={M. Sugimura and S. Kitayama and K. Morita and M. Irifune and T. Takarada and M. Kawahara and T. Dohi},
  journal={Toxicology letters},
  year={2001},
  volume={123 1},
  pages={
          69-76
        }
}
Although the neurotransmitter uptake system is considered a possible target for the presynaptic action of anesthetic agents, observations are inconsistent concerning effects on the transporter and their clinical relevance. The present study examined the effects of volatile and intravenous anesthetics on the uptake of GABA, glutamate and dopamine in COS cells heterologously expressing the transporters for these neurotransmitters and in the rat brain synaptosomes. Halothane and isoflurane, but… Expand
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