Effects of vitamin E on cardiovascular outcomes in people with mild-to-moderate renal insufficiency: results of the HOPE study.

@article{Mann2004EffectsOV,
  title={Effects of vitamin E on cardiovascular outcomes in people with mild-to-moderate renal insufficiency: results of the HOPE study.},
  author={Johannes F. E. Mann and Eva M. Lonn and Qilong Yi and Hertzel C. Gerstein and Byron J Hoogwerf and Janice Pogue and Jackie Bosch and Gilles R. Dagenais and Salim Yusuf},
  journal={Kidney international},
  year={2004},
  volume={65 4},
  pages={1375-80}
}
BACKGROUND A controlled trial reported cardiovascular benefits of vitamin E in terminal renal insufficiency. There are no data for renal insufficiency before the stage of terminal renal failure. We evaluated effects of vitamin E supplementation on cardiovascular and renal outcomes in 993 people with a serum creatinine > or =1.4 to 2.3 mg/dL. METHODS Post-hoc analysis of a randomized trial that compared treatment with natural source vitamin E (400 IU/day) to placebo in 9541 people, 993 of… CONTINUE READING

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