Effects of vitamin D-induced chronic hypercalcemia on rat renal cortical plasma membranes and mitochondria.

@article{Levi1987EffectsOV,
  title={Effects of vitamin D-induced chronic hypercalcemia on rat renal cortical plasma membranes and mitochondria.},
  author={Moshe Levi and Bruce A Molitoris and Thomas J. Burke and Robert Schrier and Francis R. Simon},
  journal={The American journal of physiology},
  year={1987},
  volume={252 2 Pt 2},
  pages={F267-75}
}
Increases in intracellular and mitochondrial calcium content that accompany ischemic and toxic acute renal failure have been suggested to mediate renal tubular cell injury and dysfunction, but the mechanism(s) are unknown. We studied the effects of in vivo vitamin D-induced chronic hypercalcemia on rat renal cortical brush-border and basolateral membranes and mitochondria. In the brush-border membrane, hypercalcemia caused significant decreases in alkaline phosphatase-specific activity, total… CONTINUE READING