Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses

@article{Galluzzi2013EffectsOV,
  title={Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses},
  author={Lorenzo Galluzzi and Erika Vacchelli and Jorg Michels and Paloma Gonz{\'a}lez Garc{\'i}a and Oliver Kepp and Laura Senovilla and Ilio Vitale and Guido Kroemer},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={4995-5004}
}
Pyridoxal-5′-phosphate (PLP), the bioactive form of vitamin B6, reportedly functions as a prosthetic group for >4% of classified enzymatic activities of the cell. It is therefore not surprising that alterations of vitamin B6 metabolism have been associated with multiple human diseases. As a striking example, mutations in the gene coding for antiquitin, an evolutionary old aldehyde dehydrogenase, result in pyridoxine-dependent seizures, owing to the accumulation of a metabolic intermediate that… CONTINUE READING