Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver.

@article{Brunaud2003EffectsOV,
  title={Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver.},
  author={Laurent Brunaud and J Alberto and Ahmet Ayav and Philippe G{\'e}rard and Far{\`e}s Namour and Laurent Antunes and Marc Braun and J P Bronowicki and Laurent Bresler and Jean-Louis Gu{\'e}ant},
  journal={Clinical chemistry and laboratory medicine},
  year={2003},
  volume={41 8},
  pages={1012-9}
}
Deficiencies of the major dietary sources of methyl groups, methionine and choline, lead to the formation of liver cancer in rodents. The most widely investigated hypothesis has been that dietary methyl insufficiency results in abnormal DNA methylation. Vitamin B12 and folate also play important roles in DNA methylation since these two coenzymes are required for the synthesis of methionine and S-adenosyl methionine, the common methyl donor required for the maintenance of methylation patterns in… CONTINUE READING

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