Effects of visual experience on activity-dependent gene regulation in cortex

@article{Majdan2006EffectsOV,
  title={Effects of visual experience on activity-dependent gene regulation in cortex},
  author={Marta Majdan and Carla J. Shatz},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={650-659}
}
There are critical periods in development when sensory experience directs the maturation of synapses and circuits within neocortex. We report that the critical period in mouse visual cortex has a specific molecular logic of gene regulation. Four days of visual deprivation regulated one set of genes during the critical period, and different sets before or after. Dark rearing perturbed the regulation of these age-specific gene sets. In addition, a 'common gene set', comprised of target genes… CONTINUE READING

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