Effects of viral strain, transgene position, and target cell type on replication kinetics, genomic stability, and transgene expression of replication-competent murine leukemia virus-based vectors.

@article{Paar2007EffectsOV,
  title={Effects of viral strain, transgene position, and target cell type on replication kinetics, genomic stability, and transgene expression of replication-competent murine leukemia virus-based vectors.},
  author={Matthias Paar and Sonja Schwab and Doris Rosenfellner and Brian Salmons and Walter H. G{\"u}nzburg and Matthias Renner and Daniel Portsmouth},
  journal={Journal of virology},
  year={2007},
  volume={81 13},
  pages={6973-83}
}
The limited efficiency of in vivo gene transfer by replication-deficient retroviral vectors remains an obstacle to achieving effective gene therapy for solid tumors. One approach to circumvent this problem is the use of replication-competent retroviral vectors. However, the application of such vectors is at a comparatively early stage and the effects which virus strain, transgene cassette position, and target cell can exert on vector spread kinetics, genomic stability, and transgene expression… CONTINUE READING