Effects of very low birthweight on brain structure in adulthood

  title={Effects of very low birthweight on brain structure in adulthood},
  author={Matthew P. G. Allin and Maxwell P. Henderson and John Suckling and Chiara Nosarti and Teresa Rushe and Paul V. Fearon and Ann L. Stewart and E. T. Bullmore and Larry Rifkin and Robin M. Murray},
  journal={Developmental Medicine \& Child Neurology},
Very‐low‐birth weight (VLBW) individuals are at high risk of brain injury in the perinatal period. We wished to determine how such early brain lesions affect brain structure in adulthood. Thirty‐two VLBW adults (20 female, 12 male) and 18 term, normal birthweight sibling control individuals (nine female, nine male) underwent structural MRI at a mean age of 23 years 4 months (range 17 to 33 years; SD 3.4). Images were analyzed using an automated tissue segmentation algorithm in order to estimate… 
Trajectories of brain development in school-age children born preterm with very low birth weight
Divergent or “catch-up” growth in terms of cortical thickness, surface area, and volumes of subcortical gray matter structures and corpus callosum in children born preterm/VLBW and did not find group × time interactions.
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Lower basal ganglia and thalamic volumes and slower growth rates in the VP group were associated with poorer cognition, academic achievement and motor function at 7 years, and this contributed to poorer functional outcomes.
Combining advanced MRI and EEG techniques better explains long-term motor outcome after very preterm birth
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This work provides a method and normative dataset that offer a more precise characterization of the cerebral consequences of preterm birth by profiling the individual neonatal brain by creating normative curves characterizing brain volumetric development in 274 term-born infants.
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Adolescents who were born very preterm have decreased brain volumes.
Individuals who were born very preterm continue to show noticeable decrements in brain volumes and striking increases in lateral ventricular volume into adolescence, and the functional significance of these abnormalities merits further investigation.
Cranial magnetic resonance imaging and school performance in very low birth weight infants in adolescence
The difficulties experienced by VLBW children at school are unlikely to be the result of perinatal brain injury, but they might to be attributable to the effects of poor postnatal growth.
Psychiatric outcomes in low-birth-weight children at age 6 years: relation to neonatal cranial ultrasound abnormalities.
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Brain structure and neurocognitive and behavioural function in adolescents who were born very preterm
Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical gray matter volume at term
PVL in the premature infant is shown for the first time to be followed by impaired cerebral cortical development, and these findings may provide insight into the anatomical correlate for the intellectual deficits associated with PVL in the prematurely infant.
The Etiology and Outcome of Cerebral Ventriculomegaly at Term in Very Low Birth Weight Preterm Infants
The data suggest that, for preterm neonates, VM at term is a consequence of the vulnerability of the developing brain and its presence is an important and independent predictor of adverse cognitive and motor development at 4.5 years' CA.
Cognitive and motor function and the size of the cerebellum in adolescents born very pre-term.
There were significant associations between cerebellar volume and several cognitive test scores, in particular the Wechsler Intelligence Scale for Children-Revised, the Kaufman Assessment Battery for Children and the Schonnel reading age, which provides further evidence implicating the cerebellum in cognition.
Regional brain volume abnormalities and long-term cognitive outcome in preterm infants.
The data indicate that preterm birth is associated with regionally specific, long-term reductions in brain volume and that morphological abnormalities are, in turn, associated with poorer cognitive outcome.
Hippocampal Volume and Everyday Memory in Children of Very Low Birth Weight
The preterm group had significantly smaller hippocampal volumes bilaterally, despite equivalent head size, and showed specific deficits in certain aspects of everyday memory, both on objective testing and as indicated by parental questionnaires.
Quantitative magnetic resonance imaging of human brain development: ages 4–18