Effects of veratridine on sodium currents and fluxes.

@article{Ulbricht1998EffectsOV,
  title={Effects of veratridine on sodium currents and fluxes.},
  author={Werner Ulbricht},
  journal={Reviews of physiology, biochemistry and pharmacology},
  year={1998},
  volume={133},
  pages={
          1-54
        }
}
Veratridine causes Na+ channels to stay open during a sustained membrane depolarization by abolishing inactivation. The consequential Na+ influx, either by itself or by causing a maintained depolarization, leads to many secondary effects such as increasing pump activity, Ca2+ influx, and in turn exocytosis. If the membrane is voltage clamped in the presence of the alkaloid, a lasting depolarizing impulse induces, following the "normal" transient current, another much more slowly developing Na… CONTINUE READING
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