Effects of verapamil on the pharmacokinetics and metabolism of epirubicin

@article{Mross1993EffectsOV,
  title={Effects of verapamil on the pharmacokinetics and metabolism of epirubicin},
  author={Klaus G Mross and Katharina Hamm and Dieter Klaus Hossfeld},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1993},
  volume={31},
  pages={369-375}
}
Experimental data suggest that multidrug resistance in cancer may be overcome by using an increased dose of anticancer agent(s) in combination with a resistance-modifying agent (RMA). We studied the pharmacokinetics and metabolism of both epirubicin (EPI) and verapamil (VPL) to explore the possible pharmacokinetic interactions between these two drugs. Ten patients with advanced breast cancer were given EPI (40 mg/m2 in a daily i.v. bolus for 3 consecutive days), and five of them also received… CONTINUE READING
8 Citations
34 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincrisfine and daunomycin in human lymphoma cell lines

  • K Hfiugermann, B Benz, V Gekeler, K Schumacher, M Eichelbaum
  • Eur J Clin Pharmaco140:53-59
  • 1991
2 Excerpts

Similar Papers

Loading similar papers…