Effects of verapamil on anthracycline-induced cardiomyopathy: preliminary results of a prospective multicenter trial.

@article{Kraft1990EffectsOV,
  title={Effects of verapamil on anthracycline-induced cardiomyopathy: preliminary results of a prospective multicenter trial.},
  author={Joanny Kraft and Werner Grille and Mavis Appelt and Dieter Kurt Hossfeld and Michel F Eichelbaum and Barbara Koslowski and Klaus Quabeck and Rolf Kuse and Thomas Buechner and Wolfgang Hiddemann},
  journal={Haematology and blood transfusion},
  year={1990},
  volume={33},
  pages={
          566-70
        }
}
Previous investigations in animals and one retrospective study in man suggest that verapamil can prevent anthracycline-induced cardiomyopathy. In the following study, patients with acute myeloid leukemia (AML) treated with double induction and consolidation chemotherapy (AML COOP study 1986, [3]) were randomized in a group with and without accompanying low-dose oral verapamil treatment. Since July 1986, 64 patients have been included. Thirty patients have been evaluated for pre- and… CONTINUE READING