Effects of ventrolateral medullary NMDA-receptor antagonism on biogenic amines and pressor response to muscle contraction

@article{Asmundsson1998EffectsOV,
  title={Effects of ventrolateral medullary NMDA-receptor antagonism on biogenic amines and pressor response to muscle contraction},
  author={Gudbjorn Asmundsson and David J. Mokler and Ahmmed Ally},
  journal={Neuroscience Research},
  year={1998},
  volume={32},
  pages={47-56}
}
Effects of D(-)2-amino-7-phosphonohepatanoic acid (AP-7), an N-methyl-D-aspartic acid (NMDA) receptor antagonist, administered into rostral ventrolateral medulla (RVLM) on changes in mean arterial pressure (MAP), heart rate (HR), extracellular levels of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) during static muscle contraction were investigated in anesthetized rats. Tibial nerve stimulation-evoked muscle contraction increased MAP and HR by 25+/-3 mmHg and 29+/-4 bpm, respectively… CONTINUE READING

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