Effects of vasopressor agents and epoprostenol on systemic hemodynamics and oxygen transport in fulminant hepatic failure.

@article{Wendon1992EffectsOV,
  title={Effects of vasopressor agents and epoprostenol on systemic hemodynamics and oxygen transport in fulminant hepatic failure.},
  author={Julia A. Wendon and Phillip M. Harrison and Richard Keays and Alexander E. S. Gimson and Graeme J. M. Alexander and Roger Williams},
  journal={Hepatology},
  year={1992},
  volume={15 6},
  pages={1067-71}
}
Hypotension is a serious complication in patients with fulminant hepatic failure, because it is associated with tissue hypoxia and a further compromise to end-organ function. In this study we investigated the effects of epinephrine and norepinephrine on hemodynamics and oxygen transport variables in 30 patients with fulminant hepatic failure. All had a mean arterial pressure of less than 60 mm Hg, despite adequate intravascular filling pressures. Both epinephrine (n = 15) and norepinephrine (n… CONTINUE READING
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