Effects of vasopressin on the water and ionic composition of toad bladder epithelial cells

@article{Macknight1971EffectsOV,
  title={Effects of vasopressin on the water and ionic composition of toad bladder epithelial cells},
  author={Anthony D. C. Macknight and Alexander Leaf and Mortimer M. Civan},
  journal={The Journal of Membrane Biology},
  year={1971},
  volume={6},
  pages={127-137}
}
Isolated sheets of epithelial cells as well as epithelial cells scraped from paired hemibladders mounted in chambers both showed significant increases in water, sodium and chloride contents after exposure to vasopressin (100 mU/ml), without any change in potassium content. In the isolated cells these changes were prevented by amiloride (10−5 m), suggesting that the gain of sodium after vasopressin occurs across the mucosal membrane. This hypothesis was confirmed in experiments in which it was… CONTINUE READING

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