Corpus ID: 31647158

Effects of various concomitant medications on gastric alcohol dehydrogenase and the first-pass metabolism of ethanol.

  title={Effects of various concomitant medications on gastric alcohol dehydrogenase and the first-pass metabolism of ethanol.},
  author={Robert H. Palmer and William O. Frank and Ponnal Nambi and Jeffrey D. Wetherington and Margaret Fox},
  journal={The American journal of gastroenterology},
  volume={86 12},
Inhibition of gastric alcohol dehydrogenase (ADH) has been shown to enhance alcohol absorption in man under certain circumstances. To determine whether various medications might affect alcohol absorption, we screened 18 compounds for an effect on ADH. Salicylic acid, acetaminophen, propranolol, ethacrynic acid, and three H2-receptor antagonists all inhibited rat gastric ADH in vitro, indicating that several commonly used medications have the potential to enhance alcohol absorption. Of these… Expand
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Inhibition of human alcohol and aldehyde dehydrogenases by acetaminophen: Assessment of the effects on first-pass metabolism of ethanol.
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