Effects of variations in duodenal glucose load on blood pressure, heart rate, superior mesenteric artery blood flow and plasma noradrenaline in healthy young and older subjects.
@article{Trahair2012EffectsOV, title={Effects of variations in duodenal glucose load on blood pressure, heart rate, superior mesenteric artery blood flow and plasma noradrenaline in healthy young and older subjects.}, author={Laurence G. Trahair and Lora Vanis and Diana Gentilcore and Kylie Lange and Christopher K. Rayner and Michael Horowitz and Karen L Jones}, journal={Clinical science}, year={2012}, volume={122 6}, pages={ 271-9 } }
PPH (postprandial hypotension), leading to increased morbidity and mortality, is an important clinical problem, particularly in the elderly and individuals with autonomic dysfunction. The magnitude of the postprandial fall in BP (blood pressure) appears to be dependent on the rate of nutrient entry into the small intestine and may be related to changes in splanchnic blood flow and sympathetic nerve activity. We aimed at determining the comparative effects of different ID (intraduodenal) glucose…
24 Citations
Comparative effects of small intestinal glucose on blood pressure, heart rate, and noradrenaline responses in obese and healthy subjects
- Medicine, BiologyPhysiological reports
- 2018
It is concluded that cardiovascular and sympathetic responses to intraduodenal glucose infusion are comparable between obese and control subjects, and dependent on the rate of glucose delivery.
Effects of variations in intragastric volume on blood pressure and splanchnic blood flow during intraduodenal glucose infusion in healthy older subjects.
- MedicineAmerican journal of physiology. Regulatory, integrative and comparative physiology
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Low-volume gastric distension has the capacity to abolish the fall in BP induced by intraduodenal glucose in healthy older subjects without affecting SMA blood flow or MVR, and support the concept that nonnutrient gastricdistension prior to a meal has potential therapeutic applications in the management of postprandial hypotension.
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The comparative effects of water and glucose drinks on cardiac hemodynamics in healthy older subjects and individuals with PPH indicate that the hypotensive response to oral glucose is associated with inadequate compensatory increases in CO and HR, whereas the pressor response to water ingestion is maintained and, possibly, exaggerated.
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- MedicineThe Journal of clinical endocrinology and metabolism
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In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow.
Effects of intraduodenal administration of the artificial sweetener sucralose on blood pressure and superior mesenteric artery blood flow in healthy older subjects.
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In healthy older subjects, intraduodenal administration of the artificial sweetener sucralose was not associated with changes in BP or SMA blood flow and further studies are warranted to determine the potential role for artificial sweeteners as a therapy for PPH.
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In critically ill patients aged >65 years, stimulation of SMA flow by small intestinal glucose infusion may be attenuated, which could account for the reduction in glucose absorption.
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