Effects of variations in duodenal glucose load on blood pressure, heart rate, superior mesenteric artery blood flow and plasma noradrenaline in healthy young and older subjects.

@article{Trahair2012EffectsOV,
  title={Effects of variations in duodenal glucose load on blood pressure, heart rate, superior mesenteric artery blood flow and plasma noradrenaline in healthy young and older subjects.},
  author={Laurence G. Trahair and Lora Vanis and Diana Gentilcore and Kylie Lange and Christopher K. Rayner and Michael Horowitz and Karen L Jones},
  journal={Clinical science},
  year={2012},
  volume={122 6},
  pages={
          271-9
        }
}
PPH (postprandial hypotension), leading to increased morbidity and mortality, is an important clinical problem, particularly in the elderly and individuals with autonomic dysfunction. The magnitude of the postprandial fall in BP (blood pressure) appears to be dependent on the rate of nutrient entry into the small intestine and may be related to changes in splanchnic blood flow and sympathetic nerve activity. We aimed at determining the comparative effects of different ID (intraduodenal) glucose… 
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24 Citations
Background Citations
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Methods Citations
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Results Citations
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Comparative effects of small intestinal glucose on blood pressure, heart rate, and noradrenaline responses in obese and healthy subjects

It is concluded that cardiovascular and sympathetic responses to intraduodenal glucose infusion are comparable between obese and control subjects, and dependent on the rate of glucose delivery.

Effects of variations in intragastric volume on blood pressure and splanchnic blood flow during intraduodenal glucose infusion in healthy older subjects.

Low-volume gastric distension has the capacity to abolish the fall in BP induced by intraduodenal glucose in healthy older subjects without affecting SMA blood flow or MVR, and support the concept that nonnutrient gastricdistension prior to a meal has potential therapeutic applications in the management of postprandial hypotension.

Comparative effects of glucose and water drinks on blood pressure and cardiac function in older subjects with and without postprandial hypotension

The comparative effects of water and glucose drinks on cardiac hemodynamics in healthy older subjects and individuals with PPH indicate that the hypotensive response to oral glucose is associated with inadequate compensatory increases in CO and HR, whereas the pressor response to water ingestion is maintained and, possibly, exaggerated.

Effects of exogenous glucagon-like peptide-1 on the blood pressure, heart rate, mesenteric blood flow, and glycemic responses to intraduodenal glucose in healthy older subjects.

In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow.

Effects of intraduodenal administration of the artificial sweetener sucralose on blood pressure and superior mesenteric artery blood flow in healthy older subjects.

In healthy older subjects, intraduodenal administration of the artificial sweetener sucralose was not associated with changes in BP or SMA blood flow and further studies are warranted to determine the potential role for artificial sweeteners as a therapy for PPH.

Mesenteric blood flow, glucose absorption and blood pressure responses to small intestinal glucose in critically ill patients older than 65 years

In critically ill patients aged >65 years, stimulation of SMA flow by small intestinal glucose infusion may be attenuated, which could account for the reduction in glucose absorption.

Effect of blood insulin level on postprandial hypotension in elderly people

PPH tends to occur in elderly people with elevated basal blood pressure before meal, and PPH is associated with an abnormal increase of postprandial insulin secretion.

Nutrient stimulation of mesenteric blood flow - implications for older critically ill patients

Evidence is provided that postprandial hypotension is likely to be an unrecognised problem in older survivors of critical illness and potential options for management are discussed.

Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men

The effects of whey-protein containing drinks to lower BP and increase HR appear to be primarily dependent on their energy content rather than macronutrient composition and may persist for at least 3 h after ingestion,.

Regional specificity of the gut-incretin response to small intestinal glucose infusion in healthy older subjects

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