Effects of variable dietary sitostanol concentrations on plasma lipid profile and phytosterol metabolism in hamsters.

  title={Effects of variable dietary sitostanol concentrations on plasma lipid profile and phytosterol metabolism in hamsters.},
  author={Fady Y. Ntanios and Peter J. H. Jones},
  journal={Biochimica et biophysica acta},
  volume={1390 3},

The hypocholesterolaemic effects of sitostanol in the guinea pig are in part related to changes in hepatic lipids and lipoprotein composition.

The results suggest that SI might have its hypocholesterolaemic effect by reducing cholesterol absorption, which results in lower concentration of cholesterol in liver, which might possibly alter hepatic cholesterol metabolism and affect lipoprotein concentration and composition.

Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men.

Addition of blended phytosterols to a prudent North American diet improved plasma LDL-cholesterol concentrations by mechanisms that did not result in significant changes in endogenous cholesterol synthesis in hypercholesterolemic men.

Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters

Results suggest that, although phytosterols reduce T-C and HDL-C levels, policosanols have no significant favorable effect in changing lipid levels in hamsters.

Plant stanol ascorbate esters reduce body weight gain through decreased energy absorption in hamsters

Stanol-ascorbate decreases body weight gain in hamster, likely due to lower energy absorption at the intestinal level, and in addition to its previously observed powerful cholesterol-lowering effect, DAPP has a hypotriglyceridemic function in hamsters.

Effects of Phytosterol Esters on Serum Lipids and Fecal Steroids Excretion in Hamsters

It is suggested that PSE effectively lowers blood cholesterol, and that there is no difference between FPS and PSE regarding their cholesterol lowering effect.

Effects of a water-soluble phytostanol ester on plasma cholesterol levels and red blood cell fragility in hamsters

It is demonstrated that DAPP lowers cholesterol more efficiently than free stanols, without an adverse effect on erythrocyte fragility in hamsters.

Beneficial effects of plant sterols/stanols-containing milk powder on lipid metabolism in hamsters

At the highest feeding dose of PSMP, hamsters had the highest body weight gain and the lowest plasma and liver lipid contents, and PSMP showed significant effects on lowering the concentrations of plasma total cholesterol and low density lipoprotein cholesterol.



Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population.

BACKGROUND Dietary plant sterols, especially sitostanol, reduce serum cholesterol by inhibiting cholesterol absorption. Soluble sitostanol may be more effective than a less soluble preparation. We

Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia.

Partial replacement of normal dietary fat consumption by sitostanol ester margarine appears to be an effective and safe hypocholesterolemic treatment in children with FH.

Effect of full-fat or defatted rice bran on serum cholesterol

FFRB appears to increase HDL and to lower LDL in chicks, but does not always affect TC, whereas DFRB may increase all three serum lipid components.

Effects of dietary cholesterol and phytosterol overload on Wistar rat plasma lipids.

Low doses of phytosterols are sufficient to significantly decrease a plasma cholesterol enhancement induced by a dietary cholesterol overload, with the highest dose being most efficient.

Dietary phytosterols as cholesterol-lowering agents in humans.

In conclusion, addition to diet of the phytosterol sitostanol represents an effective means of improving circulating lipid profiles to reduce risk of coronary heart disease.

Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia.

  • M. Denke
  • Medicine
    The American journal of clinical nutrition
  • 1995
Although previous reports have suggested that low-dose sitostanol therapy is an effective means of reducing LDL-cholesterol concentrations, its effectiveness may be attenuated when the diet is low in cholesterol.

Effects of unsaturated and saturated dietary plant sterols on their serum contents.

Serum plant sterols and their relation to cholesterol absorption.

The findings suggest that, in general, serum levels of noncholesterol sterols are effectively determined by the absorption which in turn is proportionate to the fractional absorption of cholesterol.