Effects of valproic acid, a histone deacetylase inhibitor, on improvement of locomotor function in rat spinal cord injury based on epigenetic science.

@article{Abdanipour2012EffectsOV,
  title={Effects of valproic acid, a histone deacetylase inhibitor, on improvement of locomotor function in rat spinal cord injury based on epigenetic science.},
  author={Alireza Abdanipour and Hermann Josef Schluesener and Taki Tiraihi},
  journal={Iranian biomedical journal},
  year={2012},
  volume={16 2},
  pages={90-100}
}
BACKGROUND The primary phase of traumatic spinal cord injury (SCI) starts by a complex local inflammatory reaction such as secretion of pro-inflammatory cytokines from microglia and injured cells that substantially contribute to exacerbating pathogenic events in secondary phase. Valproic acid (VPA) is a histone deacetylase inhibitor. Acetylation of histones is critical to cellular inflammatory and repair processes. METHODS In this study, rats were randomly assigned to five experimental groups… CONTINUE READING
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