Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy

  title={Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy},
  author={Martin Hill and Jana Zarubova and Petr Marusic and Jana Vrb{\'i}kov{\'a} and Marta Vel{\'i}kov{\'a} and Radmila Kancheva and Lyudmila Kancheva and Jana Kub{\'a}tov{\'a} and Michaela Du{\vs}kov{\'a} and Ludmila Zamrazilov{\'a} and Hana Kazihn{\'i}tkov{\'a} and Kateřina {\vS}imůnkov{\'a} and Ľuboslav St{\'a}rka},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • M. Hill, J. Zarubova, Ľ. Stárka
  • Published 1 October 2010
  • Medicine, Biology, Psychology
  • The Journal of Steroid Biochemistry and Molecular Biology
Effects of carbamazepine on male reproductive hormones
Sexual hormone serum levels among men with newly diagnosed epilepsy are investigated, before starting any antiepileptic drug (AED), and then after starting carbamazepine (CBZ), to determine the role and effects of epilepsy versus CBZ in creating reproductive endocrine disorders.
Dehydroepiandrosterone, its metabolites and ion channels
Psychotropics and Male Reproduction.
Psychotropic drugs, including antidepressants, antipsychotics, and anticonvulsants, all have negative effects on sexual function and semen quality and are less pronounced for some medications, allowing their effects to be managed to some extent.
The antiepileptic effect of sodium valproate during different phases of the estrous cycle in PTZ-induced seizures in rats
The results of this study showed that VPA significantly improved antiepileptic parameters including ITMS, ITTS, SD, and MR, in which they were significantly more prominent during the luteal phase than the follicular phase.
Steroid Sulfation in Neurodegenerative Diseases
The shifted balance towards unconjugated steroids can participate in the pathophysiology of PD and anti-inflammatory effects of DHEAS may counteract the MS.
The Antiepileptic Effect of Ghrelin During Different Phases of the Estrous Cycle in PTZ-Induced Seizures in Rat
Ghrelin has antiepileptic effects which are more prominent during luteal phase than follicular phase, and there was no mortality after ICV injection of Ghrelin during lutenal and follicular phases compared to control group.
Management of antiepileptic drug–induced nutrition-related adverse effects
The adverse effects of AEDs on some of the nutrition-related issues, including bone health, body weight, glucose and lipid metabolism, vitamin homeostasis, antioxidant defense system, and pregnancy are reviewed.
Altered sexual and reproductive functions in epileptic men taking carbamazepine.
Epileptic men with epileptic seizures controlled by carbamazepine present with changes in hormonal levels, altered semen quality, ED, and a reduction in coital frequency.


Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy
VPA increases serum androgen concentrations in men with epilepsy, and the endocrine effects of CBZ and OXC were different, because CBZ appears to decrease the bioactivity of androgens, whereas OxC does not.
Effects of long-term antiepileptic therapy on the catabolism of testosterone.
The results suggest that an induction of the hepatic synthesis of sex hormone binding globulin may be the mechanism by which the antiepileptic drugs lower the levels of free testosterone in serum.
Early hormonal changes during valproate or carbamazepine treatment
Hormonal changes occur after only 1 month’s use of VPA or CBZ, but the profile of hormonal changes appears to be different in women than in men.
Carbamazepine, Phenytoin, Sex Hormones, and Sexual Function in Men with Epilepsy
Serum sex hormone binding globulin levels increased and free androgen index (FAI) decreased during CBZ treatment, and these changes correlated with duration of CBZ therapy, which may be the primary cause of hyposexuality common in men with epilepsy.
Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology.
The present study demonstrates that the serum concentrations of testosterone, DHT, E1, and E2 are poor indicators of total androgenic and estrogenic activity, and the esterified metabolites of DHT appear as reliable markers of the total androgens pool.
Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy
In conclusion, drug‐specific endocrine effects of VPA and CBZ were found in men with epilepsy, and a strict age matching were found to be of importance in the evaluation of endocrine function in men.
Anticonvulsant Activity of Androsterone and Etiocholanolone
Levels of the major metabolites of testosterone—androsterone and 5α,3α‐A, a neurosteroid that acts as a positive allosteric modulator of GABAA receptors, and its 5β‐epimer etiocholanolone, also may be reduced in epilepsy, to determine whether these endogenous steroid metabolites can protect against seizures.
Effect of epilepsy and antiepileptic drugs on male reproductive health
CBZ, OXC, and VPA are associated with sperm abnormalities in men with epilepsy, in addition, VPA-treated men with generalized epilepsy who have abnormal sperm may have reduced testicular volume.