Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy.

@article{Hill2010EffectsOV,
  title={Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy.},
  author={Martin Hill and Jana Z{\'a}rubov{\'a} and Petr Marusic and Jana Vrb{\'i}kov{\'a} and Marta Vel{\'i}kov{\'a} and Radmila Kancheva and Lyudmila Kancheva and Jana Kub{\'a}tov{\'a} and Michaela Du{\vs}kov{\'a} and Ludmila Zamrazilov{\'a} and Hana Kazihn{\'i}tkov{\'a} and Kateřina {\vS}imůnkov{\'a} and Luboslav St{\'a}rka},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2010},
  volume={122 4},
  pages={239-52}
}
Only limited data is available concerning the role of unconjugated Δ(5) C19-steroids and almost no data exists regarding the neuroactive C21 and C19 3α-hydroxy-5α/β-metabolites in men with epilepsy. To evaluate the alterations in serum neuroactive steroids and related substances in adult men with epilepsy on valproate and carbamazepine monotherapy, we have measured 26 unconjugated steroids, 18 steroid polar conjugates, gonadotropins and sex hormone binding globulin (SHBG) in 6 and 11 patients… CONTINUE READING