Effects of vaccine strain mutations in domain V of the internal ribosome entry segment compared in the wild type poliovirus type 1 context.

@article{Malnou2004EffectsOV,
  title={Effects of vaccine strain mutations in domain V of the internal ribosome entry segment compared in the wild type poliovirus type 1 context.},
  author={C{\'e}cile E Malnou and Andreas Werner and Andrew M Borman and Eric Westhof and Katherine M. Kean},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 11},
  pages={10261-9}
}
Initiation of poliovirus (PV) protein synthesis is governed by an internal ribosome entry segment structured into several domains including domain V, which is accepted to be important in PV neurovirulence because it harbors an attenuating mutation in each of the vaccine strains developed by A. Sabin. To better understand how these single point mutations exert their effects, we placed each of them into the same genomic context, that of PV type 1. Only the mutation equivalent to the Sabin type 3… CONTINUE READING

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