Effects of uricosuric and antiuricosuric agents on urate transport in human brush-border membrane vesicles.

@article{RochRamel1997EffectsOU,
  title={Effects of uricosuric and antiuricosuric agents on urate transport in human brush-border membrane vesicles.},
  author={Françoise Roch-Ramel and Barbara Guisan and Jacques Diezi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={280 2},
  pages={839-45}
}
Inhibition of [14C]-urate uptake by uricosuric and antiuricosuric agents was investigated in human brush-border membrane vesicles, urate being transported either by anion exchange mechanisms or by voltage sensitive pathway. The IC50 for drugs on [14C]-urate uptake in vesicles loaded with 1 mM cold urate or with 5 mM lactate was, respectively: 0.7 and 0.3 microM for benzbromarone; 6 and 4 microM for salicylate; 133 and 13 microM for losartan; 520 and 190 microM for sulfinpyrazone and 807 and 150… CONTINUE READING
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