Effects of urease-induced hyperammonemia in mouse liver. Ultrastructural, stereologic and biochemical study.

@article{OConnor1984EffectsOU,
  title={Effects of urease-induced hyperammonemia in mouse liver. Ultrastructural, stereologic and biochemical study.},
  author={Jim E. O'Connor and Jaime Renau-Piqueras and Santiago Grisol{\^i}a},
  journal={Virchows Archiv. B, Cell pathology including molecular pathology},
  year={1984},
  volume={46 3},
  pages={187-97}
}
Intraperitoneal injections of urease induced a marked and sustained hyperammonemia in mice. Ultrastructural and stereologic analysis of hepatocytes from urease-treated mice showed striking changes in the mitochondria, rough and smooth endoplasmic reticulum and lysosomes. Thus, mitochondria became larger and rounder, and contained a less electron-dense matrix although their volume density remained similar to that of control cells. In addition, increases in the smooth and rough reticulum and the… CONTINUE READING