Effects of ultralow-dose transdermal estradiol on bone mineral density: a randomized clinical trial.

@article{Ettinger2004EffectsOU,
  title={Effects of ultralow-dose transdermal estradiol on bone mineral density: a randomized clinical trial.},
  author={Bruce Ettinger and Kristine E Ensrud and Robert T. Wallace and Karen C Johnson and Steve Cummings and Vladimir I Yankov and Eric Vittinghoff and Deborah Grady},
  journal={Obstetrics and gynecology},
  year={2004},
  volume={104 3},
  pages={443-51}
}
OBJECTIVE Because small increments in levels of endogenous plasma estradiol are associated with higher postmenopausal bone mineral density, we investigated the safety and effectiveness in preventing bone loss of unopposed, very-low-dose transdermal estradiol for postmenopausal women. METHODS This was a randomized, placebo-controlled, double-blind trial with 2-year follow-up at 9 United States clinical centers. The study population comprised 417 postmenopausal women, aged 60-80 years, with… CONTINUE READING
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  • U. S. Preventive Service
  • Postmenopausal hormone replacement therapy for…
  • 2004
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