Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion.

@article{Fujita2009EffectsOU,
  title={Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion.},
  author={Katsuhide Fujita and Masanori Horie and Haruhisa Kato and Shigehisa Endoh and Mie Suzuki and Ayako Nakamura and Arisa Miyauchi and Kazuhiro Yamamoto and Shinichi Kinugasa and Keiko Nishio and Yasukazu Yoshida and Hitoshi Iwahashi and Junko Nakanishi},
  journal={Toxicology letters},
  year={2009},
  volume={191 2-3},
  pages={109-17}
}
Assessing in vitro cellular responses to molecular events is an effective mean to elucidate the toxicological behavior of the ultrafine nanoparticles. In this study, we utilized the DNA microarray analysis technique to determine the gene expression profiles of the human keratinocyte HaCaT cells exposed to anatase titanium dioxide (TiO(2)) particles of different (7 nm, 20 nm and 200 nm) average diameters without illumination. Cells were incubated for 24 h with TiO(2) particles, which were… CONTINUE READING

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