Corpus ID: 24627119

Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro.

@article{Wong1997EffectsOT,
  title={Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro.},
  author={W. S. Fred Wong and D S Koh and A H M Koh and Wee Lee Ting and Peter T.-H. Wong},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 1},
  pages={
          131-7
        }
}
  • W. Wong, D. Koh, +2 authors P. Wong
  • Published 1997
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
The present study was conducted to examine the effects of two protein tyrosine kinase inhibitors, genistein and tyrphostin 47, on an in vitro model of allergic asthma. Guinea pigs were sensitized with purified IgG raised against ovalbumin (OA). Isolated sensitized bronchial rings contracted in response to OA in a concentration-dependent manner, maximum contraction being achieved at 1 microg/ml. Genistein and tyrphostin 47 concentration-dependently (10-100 microM) inhibited OA-induced… Expand
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References

SHOWING 1-10 OF 53 REFERENCES
Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects.
TLDR
The leukotrienes appear to be the major and singularly most important mediators of the contraction, whereas histamine accounts for its minor residual component. Expand
Role of Tyrosine Kinases in IgE-Mediated Signal Transduction in Human Lung Mast Cells and Basophils.
TLDR
The results suggest that tyrosine kinases may have a role in IgE-dependent signal transduction in human lung mast cells and basophils but indicates that the two cell types have distinct inhibitory profiles. Expand
Interactions between leukotrienes and histamine in the anaphylactic contraction of guinea pig lung parenchyma.
The aim of the study was to investigate if antigen-induced contraction of guinea pig lung parenchyma (GPLP) was an appropriate model for the study of antileukotriene drugs. Antileukotrienes haveExpand
Epithelial modulation of thromboxane A2 and PAF involvement in IgE- and IgG-mediated guinea pig anaphylaxis.
TLDR
The results indicate that thromboxane A2 (TXA2) and PAF are potent inducers of epithelium-derived mediators in IgG- and IgE-mediated guinea pig anaphylaxis respectively. Expand
Influence of indomethacin and L-cysteine on histamine and peptidoleukotriene release from superfused tracheas taken from guinea pigs passively sensitized with IgG1 and IgE antibodies.
TLDR
There is a differential pattern of peptidoleukotriene metabolism after activation of IgG1 versus IgE receptors in guinea pig trachea, which is similar for both Abs in the presence of L-cysteine, 10 mmol/L. Expand
Role of Tyrosine Kinases in Norepinephrine‐Induced Contraction of Vascular Smooth Muscle
TLDR
The data indicate that genistein- and tyrphostin-sensitive tyrosine kinases participate in NE-induced contraction of rat aortic smooth muscle, and the enzymes appear to have a greater role in mediating the responses linked to the release of intracellular calcium. Expand
IgG vs IgE: mediators of antigen-induced guinea pig lung parenchymal contraction.
  • J. Regal
  • Chemistry, Medicine
  • Immunopharmacology
  • 1985
TLDR
A differential antagonism of IgG- and IgE-mediated airway contraction is demonstrated and it is suggested that leukotrienes are important mediators of antigen-induced lung parenchymal contraction in IgG - but not IgE -sensitized tissues. Expand
Contributory role of lung pleura to release of anaphylactic mediators from guinea pig lung in response to ovalbumin or A23187.
Previous findings revealed greater contractile responses of guinea pig lung pleural surface strips to antigen or A23187 challenge than denuded lung parenchymal strips (lung strip devoid of anyExpand
Distinct signal transduction pathways for angiotensin-II in guinea pig gastric smooth muscle: differential blockade by indomethacin and tyrosine kinase inhibitors.
In guinea pig gastric longitudinal (LM) and circular (CM) muscle strips, angiotensin-II (Ang-II) caused a concentration-dependent contraction that required extracellular calcium and that could not beExpand
Pharmacologic evaluation of A23187-induced contractions of three distinct preparations of guinea pig lung parenchymal strips.
TLDR
Examination of the pharmacologic profiles of three distinct guinea pig lung parenchymal strips revealed that the density of mast cells in the smooth muscle of lung pleura was as high as that found in the bronchiolar area and mast cells were scarcely identified in the alveolar parenchyma. Expand
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4
5
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