• Corpus ID: 24627119

Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro.

@article{Wong1997EffectsOT,
  title={Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro.},
  author={W. S. Fred Wong and D S Koh and A H M Koh and Wee Lee Ting and Peter T.-H. Wong},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 1},
  pages={
          131-7
        }
}
  • W. WongD. Koh P. Wong
  • Published 1 October 1997
  • Biology, Medicine, Chemistry
  • The Journal of pharmacology and experimental therapeutics
The present study was conducted to examine the effects of two protein tyrosine kinase inhibitors, genistein and tyrphostin 47, on an in vitro model of allergic asthma. Guinea pigs were sensitized with purified IgG raised against ovalbumin (OA). Isolated sensitized bronchial rings contracted in response to OA in a concentration-dependent manner, maximum contraction being achieved at 1 microg/ml. Genistein and tyrphostin 47 concentration-dependently (10-100 microM) inhibited OA-induced… 

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