Effects of typical inducers on olfactory xenobiotic-metabolizing enzyme, transporter, and transcription factor expression in rats.

@article{Thiebaud2010EffectsOT,
  title={Effects of typical inducers on olfactory xenobiotic-metabolizing enzyme, transporter, and transcription factor expression in rats.},
  author={Nicolas Thiebaud and Maud Sigoillot and Jo{\"e}lle Chevalier and Yves Artur and J. M. Heydel and Anne-Marie Le Bon},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2010},
  volume={38 10},
  pages={1865-75}
}
Several xenobiotic-metabolizing enzymes (XMEs) have been identified in the olfactory mucosa (OM) of mammals. However, the molecular mechanisms underlying the regulation of these enzymes have been little explored. In particular, information on the expression of the transcriptional factors in this tissue is quite limited. The aim of the present study was to examine the impact of five typical inducers, Aroclor 1254, 3-methylcholanthrene, dexamethasone, phenobarbital, and ethoxyquin, on the… CONTINUE READING

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Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa.

Drug metabolism and disposition: the biological fate of chemicals • 2005
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