Effects of two fungicides with multiple modes of action on reproductive endocrine function in the fathead minnow (Pimephales promelas).

@article{Ankley2005EffectsOT,
  title={Effects of two fungicides with multiple modes of action on reproductive endocrine function in the fathead minnow (Pimephales promelas).},
  author={Gerald T. Ankley and Kathleen M. Jensen and Elizabeth J. Durhan and Elizabeth A. Makynen and Brian C Butterworth and Michael D. Kahl and Daniel L. Villeneuve and Ann L Linnum and Leon Earl Gray and Mary C Cardon and Vickie S Wilson},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2005},
  volume={86 2},
  pages={300-8}
}
Many chemicals that adversely affect reproduction and/or development do so through multiple pathways within the reproductive tract and hypothalamic-pituitary-gonadal axis. Notable in this regard are fungicides, such as prochloraz or fenarimol, which in mammals have the potential to impact endocrine function through inhibition of CYP enzymes involved in steroid metabolism, as well as through antagonism of the androgen receptor(s). The objective of our studies was to assess the effects of… CONTINUE READING
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