Effects of two antihypertensive agents on lipids, lipoproteins, and apoproteins A and B. Comparison of prazosin and atenolol.

@article{Rouffy1986EffectsOT,
  title={Effects of two antihypertensive agents on lipids, lipoproteins, and apoproteins A and B. Comparison of prazosin and atenolol.},
  author={J. Rouffy and J. Jaillard},
  journal={The American journal of medicine},
  year={1986},
  volume={80 2A},
  pages={
          100-3
        }
}
To compare the effects of prazosin and atenolol on plasma lipid concentrations, 60 patients with arterial hypertension (diastolic 90 to 120 mm Hg, systolic 160 to 200 mm Hg) were allocated at random to one of two treatment groups. The lipid profile included the determination of total cholesterol and triglyceride levels by ultracentrifugation, and assays of apoproteins A1 and B by laser immunonephelometry. Determinations were performed 30 days before and on the first, 90th, and 180th days of… Expand
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References

SHOWING 1-10 OF 14 REFERENCES
Effects of alpha- and beta-blocker antihypertensive therapy on blood lipids: a multicenter trial.
  • Y. Gotō
  • Medicine
  • The American journal of medicine
  • 1984
TLDR
A randomized 12-week multicenter trial was conducted to clarify the effects of prazosin and propranolol on serum lipids in essential hypertensive patients with blood pressures of at least 160mm Hg systolic and 95 mm Hg diastolic after a minimum of four weeks treatment with trichlormethiazide and both drugs showed equally good antihypertensive effects. Expand
Effect of Prazosin on Serum Lipids
TLDR
Prazosin would seem to be an effective and safe antihypertensive agent with considerable favorable effects on serum lipids. Expand
Effects of long-term prazosin therapy on lipoprotein metabolism in hypertensive patients.
TLDR
Prazosin monotherapy is concluded to have favorable effects on serum lipids and can be considered suitable for long-term antihypertensive therapy. Expand
EFFECT OF PROPRANOLOL AND PRAZOSIN ON BLOOD LIPIDS The Oslo Study
TLDR
In 23 hypertensive men, aged 47-55, propranolol reduced serum high-density-lipoprotein (HDL) cholesterol by 13% and prazosin reduced total serum cholesterol by 9%, LDL+VLDL cholesterol by 10%, and total triglycerides by 16%. Expand
Serum lipoprotein changes during atenolol treatment of essential hypertension
TLDR
Some patients on long term treatment with atenolol seem to receive the benefit of normotension at the cost of hypertriglyceridaemia, which may have practical implications, since hypertrigenicemia constitutes an important risk factor for atherosclerosis. Expand
Effects of prazosin and propranolol on serum lipids in patients with essential hypertension.
The effects of prazosin and propranolol on total serum cholesterol concentration, low-density lipoprotein and high-density lipoprotein cholesterol fractions, and serum triglyceride concentration wereExpand
Comparative effects of propranolol and prazosin upon serum lipids in thiazide- treated hypertensive patients.
TLDR
With the addition of prazosin to the polythiazide regimen, there was a significant increase in serum high-density lipoprotein cholesterol when compared with the placebo. Expand
Atenolol v placebo in mild hypertension: renal metabolic and stress antipressor effects.
TLDR
The cardioselectivity of atenolol does not impair its anti-hypertensive effect and may be associated with less effect on renal function, and the metabolic effects of atanolol seem to differ from those of metoprolol. Expand
PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE
TLDR
The body cholesterol pool increases with decreasing plasma-high-density-lipoprotein (H.D.L.) but is unrelated to the plasma concentrations of total cholesterol and other lipoproteins, and it is proposed that a reduction of plasma-H.H.L.D., is reduced in several conditions associated with an increased risk of future ischaemic heart-disease, by impairing the clearance of cholesterol from the arterial wall. Expand
ARE APOLIPOPROTEINS BETTER DISCRIMINATORS THAN LIPIDS FOR ATHEROSCLEROSIS?
TLDR
The protein moiety of lipoproteins is a better discriminator than lipids between atherosclerotic subjects and controls and in the sixth to eighth decades. Expand
...
1
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