Effects of turmeric on the activities of benzo(a)pyrene-induced cytochrome P-450 isozymes.

@article{Thapliyal2001EffectsOT,
  title={Effects of turmeric on the activities of benzo(a)pyrene-induced cytochrome P-450 isozymes.},
  author={Rachana Thapliyal and Shailesh S Deshpande and Girish B. Maru},
  journal={Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer},
  year={2001},
  volume={20 1},
  pages={
          59-63
        }
}
Turmeric and/or its main coloring component, curcumin (diferuloylmethane), have been shown to inhibit benzo(a)pyrene [B(a)P]-induced forestomach papillomas in mice. However, the mechanisms of turmeric-mediated chemoprevention are not well understood. To study the mechanisms of turmeric-mediated chemoprevention, we investigated the effects of turmeric feeding on the activities of isozymes of cytochrome P-450 (CYP450)--namely, ethoxyresorufin O-deethylase (EROD, CYP1A1) and methoxyresorufin O… CONTINUE READING
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