Effects of tumor necrosis factor-alpha treatment on mortality in murine cytomegalovirus-infected mice.

@article{Anderson1993EffectsOT,
  title={Effects of tumor necrosis factor-alpha treatment on mortality in murine cytomegalovirus-infected mice.},
  author={K P Anderson and Y S Lie and Marie Low and E H Fennie},
  journal={Antiviral research},
  year={1993},
  volume={21 4},
  pages={
          343-55
        }
}
The effects of treatment with recombinant DNA-derived Tumor Necrosis Factor-alpha (TNF-alpha) in a murine model of cytomegalovirus infection were investigated. Treatment of 3-week-old Swiss Webster mice with murine TNF-alpha prior to infection with murine cytomegalovirus (MCMV) had no demonstrable effect on mortality. However, if mice were treated prior to infection with a combination of murine IFN-gamma and murine TNF-alpha, the dose of IFN-gamma required to achieve significant reduction in… CONTINUE READING