Effects of tumor necrosis factor alpha antagonist, platelet activating factor antagonist, and nitric oxide synthase inhibitor on experimental otitis media with effusion.

@article{Kim2006EffectsOT,
  title={Effects of tumor necrosis factor alpha antagonist, platelet activating factor antagonist, and nitric oxide synthase inhibitor on experimental otitis media with effusion.},
  author={Dong Hyun Kim and Yong-Soo Park and Eun-ju Jeon and Sanghyuk Yeo and Kimberly S G Chang and Seung Kyun Lee},
  journal={The Annals of otology, rhinology, and laryngology},
  year={2006},
  volume={115 8},
  pages={
          617-23
        }
}
OBJECTIVES We studied the inflammatory responses in otitis media with effusion induced by lipopolysaccharide (LPS) in rats, and compared the preventive effects of tumor necrosis factor (TNF) soluble receptor type I (sTNFRI, a TNF-alpha antagonist), platelet activating factor antagonist, and the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME). METHODS We used 2 control groups of Sprague Dawley rats (untreated and saline-treated) and 4 experimental groups, which all… CONTINUE READING
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