Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.

@article{Weiner2010EffectsOT,
  title={Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.},
  author={Marc H Weiner and Charles A Peloquin and William J. Burman and C Luo and Melissa Engle and Thomas J. Prihoda and William R. Mac Kenzie and Erin Bliven-Sizemore and John Johnson and Andrew N Vernon},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 10},
  pages={4192-200}
}
Rifampin has concentration-dependent activity against Mycobacterium tuberculosis. However, marked intersubject variation of rifampin concentrations occurs. In this study, we evaluated rifampin pharmacokinetics in relation to tuberculosis, geographic region, race, and single nucleotide polymorphisms of the human transporter genes SLCO1B1, SLCO1B3, and MDR1. Seventy-two adults with pulmonary tuberculosis from Africa, North America, and Spain were evaluated during multidrug intensive-phase therapy… CONTINUE READING

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