Effects of tryptophan depletion in drug-free adults with autistic disorder.

@article{McDougle1996EffectsOT,
  title={Effects of tryptophan depletion in drug-free adults with autistic disorder.},
  author={Christopher J. McDougle and Stephanie Naylor and Donald J. Cohen and George K. Aghajanian and George R. Heninger and Lawrence H. Price},
  journal={Archives of general psychiatry},
  year={1996},
  volume={53 11},
  pages={993-1000}
}
BACKGROUND The primary objective of this study was to investigate the behavioral and biochemical responses to acute tryptophan depletion in drug-free adult patients with autistic disorder. METHODS Twenty drug-free adults with autistic disorder (16 men and 4 women) (mean [+/- SD] age, 30.5 +/- 8.5 years) underwent short-term tryptophan depletion in a double-blind, placebo-controlled, randomized crossover design. Patients received a 24-hour, low-tryptophan diet followed the next morning by an… CONTINUE READING
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