Effects of troglitazone on HepG2 viability and mitochondrial function.

  title={Effects of troglitazone on HepG2 viability and mitochondrial function.},
  author={Mark A. Tirmenstein and Catherine X. J. Hu and Tracy L Gales and Beverly E. Maleeff and Padma Kumar Narayanan and Edit Kurali and Timothy K. Hart and Heath C Thomas and Lester W. Schwartz},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={69 1},
Troglitazone (TRO), a member of the thiazolidinedione class of drugs, has been associated with hepatotoxicity in patients. The following in vitro study was conducted to investigate the effects of TRO on mitochondrial function and viability in a human hepatoma cell line, HepG2. TRO induced a concentration- and time-dependent increase in cell death, as measured by lactate dehydrogenase release. Exposure to 50 or 100 micro M TRO produced total loss of cell viability within 5 h. Preincubation of… CONTINUE READING
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